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KMID : 0377220000250020045
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Medical Journal of Chosun Univercity
2000 Volume.25 No. 2 p.45 ~ p.51
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E-cadherin Expression in Squamous Cell Carcinomas of the Larynx and Hypopharynx
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Do Nam-Yong
Na Han-Jo
Lee Do-Yong
Hur Jun
Choi Ji-Yun
Lee Hong-Young
LiM Sung-Chul
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Abstract
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Background and Objectives : The cell-cell adhesion molecule E-cadherin is necessary for the maintenance of the epithelial cellular structure. We were designed to confirm the significance of E-cadherin as a marker for differentiation and invasiveness of squamous cell carcinoma of the larynx and hypopharynx.
Materials and Methods : Our study was investigated for the immunohistochemical expression of the epithelium-specific cell adhesion molecule E-cadherin in formalin fixed paraffin embedded tissue specimen of 32 cases of squamous cell carcinoma of larynx and hypopharynx.
Results : The positive expression of E-cadherin was 56.3%(18 cases) in squamous cell carcinoma of the larynx and hypopharynx. Decreased E-cadherin expression was a stastistically significant correlation with a increased grade of lymph node stage and clinical stage. Reduced expression was seen in the large tumor size and poorly differentiated tumors, but these result was not statistically significant.
Conclusion : The expression of E-cadherin may be related with progression of squamous cell carcinoma of the larynx and hypopharynx. But these correlation were not sufficient for the prognostic indicators in squamous cell carcinomas of the larynx and hypopharynx.
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KEYWORD
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E-cadherin, Larygeal cancer, Hypopharygeal cancar
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